abstract：:Cytoglobin is a recently identified vertebrate globin whose functions include scavenging reactive oxygen and nitrosative species. In tumor cells, CYGB may function as a tumor suppressor gene. Here we show that knockdown of cytoglobin expression can sensitize human glioma cells to oxidative stress induced by chemical i...

journal_title：Radiation research

authors： Fang J,Ma I,Allalunis-Turner J

更新日期：2011-08-01 00:00:00

abstract：:Dose assessment after radiological disasters is imperative to decrease mortality through rationally directed medical intervention. Our goal was to identify biomarkers capable of qualitative (nonirradiated/irradiated) and/or quantitative (dose) assessment of radiation exposure. Using real-time quantitative PCR, biodosi...

journal_title：Radiation research

authors： Filiano AN,Fathallah-Shaykh HM,Fiveash J,Gage J,Cantor A,Kharbanda S,Johnson MR

更新日期：2011-07-01 00:00:00

abstract：:Blockers of the renin-angiotensin-aldosterone system (RAAS) ameliorate cognitive deficits and some aspects of brain injury after whole-brain irradiation. We investigated whether treatment with the angiotensin II type 1 receptor antagonist L-158,809 at a dose that protects cognitive function after fractionated whole-br...

journal_title：Radiation research

authors： Conner KR,Forbes ME,Lee WH,Lee YW,Riddle DR

更新日期：2011-07-01 00:00:00

abstract：:The purpose of this work was to determine how fractionated radiation used in the treatment of tumors affects the ability of cancer as well as normal cells to repair induced DNA double-strand breaks (DSBs) and how cells that have lost this ability die. Lymphocytic leukemia cells (MOLT4) were used as an experimental mod...

journal_title：Radiation research

authors： Rezáčová M,Rudolfová G,Tichý A,Bačíková A,Mutná D,Havelek R,Vávrová J,Odrážka K,Lukášová E,Kozubek S

更新日期：2011-06-01 00:00:00

abstract：:Radiation exposure from a number of terrestrial sources is associated with an increased risk for atherosclerosis. Recently, concern over whether exposure to cosmic radiation might pose a similar risk for astronauts has increased. To address this question, we examined the effect of 2 to 5 Gy iron ions ((56)Fe), a parti...

journal_title：Radiation research

authors： Yu T,Parks BW,Yu S,Srivastava R,Gupta K,Wu X,Khaled S,Chang PY,Kabarowski JH,Kucik DF

更新日期：2011-06-01 00:00:00

abstract：:It has been acknowledged for many years that radiation exposure induces delayed, non-targeted effects in the progeny of the irradiated cell. Evidence is beginning to demonstrate that among these delayed effects of radiation are epigenetic aberrations, including altered DNA methylation. To test the hypothesis that diff...

journal_title：Radiation research

authors： Goetz W,Morgan MN,Baulch JE

更新日期：2011-05-01 00:00:00

abstract：:Well-defined protocols and quality management standards are indispensable for biological dosimetry laboratories. Participation in periodic proficiency testing by interlaboratory comparisons is also required. This harmonization is essential if a cooperative network is used to respond to a mass casualty event. Here we p...

journal_title：Radiation research

authors： Di Giorgio M,Barquinero JF,Vallerga MB,Radl A,Taja MR,Seoane A,De Luca J,Oliveira MS,Valdivia P,Lima OG,Lamadrid A,Mesa JG,Aguilera IR,Cardoso TM,Carvajal YC,Maldonado CA,Espinoza ME,Martínez-López W,Méndez-Acuña L,

更新日期：2011-05-01 00:00:00

abstract：:Damage to intestine is a serious problem after accidental radiation exposure. To examine substances to ameliorate damage by postirradiation administration, we focused on the regeneration process after irradiation of the intestine. Using experimental systems, the effects of clinically used sex hormones on regeneration ...

journal_title：Radiation research

authors： Ishihara H,Tanaka I,Yakumaru H,Tanaka M,Satoh A,Ishiwata A,Yokochi K,Kurematsu A,Ueda J,Shibata T,Hachiya M,Akashi M

更新日期：2011-03-01 00:00:00

abstract：:The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...

journal_title：Radiation research

authors： Ivey RG,Moore HD,Voytovich UJ,Thienes CP,Lorentzen TD,Pogosova-Agadjanyan EL,Frayo S,Izaguirre VK,Lundberg SJ,Hedin L,Badiozamani KR,Hoofnagle AN,Stirewalt DL,Wang P,Georges GE,Gopal AK,Paulovich AG

更新日期：2011-03-01 00:00:00

abstract：:In the event of a radiation accident or attack, it will be imperative to quickly assess the amount of radiation exposure to accurately triage victims for appropriate care. RNA-based radiation dosimetry assays offer the potential to rapidly screen thousands of individuals in an efficient and cost-effective manner. Howe...

journal_title：Radiation research

authors： Pogosova-Agadjanyan EL,Fan W,Georges GE,Schwartz JL,Kepler CM,Lee H,Suchanek AL,Cronk MR,Brumbaugh A,Engel JH,Yukawa M,Zhao LP,Heimfeld S,Stirewalt DL

更新日期：2011-02-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key functional element in the DNA-PK complex that drives nonhomologous end joining (NHEJ), the predominant DNA double-strand break (DSB) repair mechanism operating to rejoin such breaks in mammalian cells after exposure to ionizing radiation. It h...

journal_title：Radiation research

authors： Nagasawa H,Little JB,Lin YF,So S,Kurimasa A,Peng Y,Brogan JR,Chen DJ,Bedford JS,Chen BP

更新日期：2011-01-01 00:00:00

abstract：:Radiation is an independent risk factor for cardiovascular and cerebrovascular disease in cancer patients. Modern radiotherapy techniques reduce the volume of the heart and major coronary vessels exposed to high doses, but some exposure is often unavoidable. Radiation damage to the myocardium is caused primarily by in...

journal_title：Radiation research

authors： Stewart FA,Hoving S,Russell NS

更新日期：2010-12-01 00:00:00

abstract：:Relatively few data are available on the prevalence of hyperthyroidism (TSH concentrations of <0.3 mIU/liter, with normal or elevated concentrations of free T4) in individuals exposed to radioiodines at low levels. The accident at the Chornobyl (Chernobyl) nuclear plant in Ukraine on April 26, 1986 exposed large numbe...

journal_title：Radiation research

authors： Hatch M,Furukawa K,Brenner A,Olinjyk V,Ron E,Zablotska L,Terekhova G,McConnell R,Markov V,Shpak V,Ostroumova E,Bouville A,Tronko M

更新日期：2010-12-01 00:00:00

abstract：:Radiation-induced neurotoxicity is a well-characterized phenomenon. However, the underlying mechanism of this toxicity is poorly understood. In the central nervous system (CNS), excitotoxic mechanisms are implicated in many neurodegenerative disease processes. Pivotal to the excitotoxic pathway is dysfunction of gluta...

journal_title：Radiation research

authors： Sanchez MC,Nelson GA,Green LM

更新日期：2010-12-01 00:00:00

abstract：:It is well established that high-LET radiations efficiently induce chromosome aberrations. However, data on the effect of protons on telomere maintenance, as involved in genomic stability, are scarce and contradictory. Here we demonstrate that high-LET protons induce telomere lengthening in human primary fibroblasts a...

journal_title：Radiation research

authors： Berardinelli F,Antoccia A,Cherubini R,De Nadal V,Gerardi S,Cirrone GA,Tanzarella C,Sgura A

更新日期：2010-11-01 00:00:00

abstract：:Alpha-particle irradiation of cells damages not only the irradiated cells but also nontargeted bystander cells. It has been proposed that the bystander effect is caused by oxidants and free radicals generated by the radiation. Recent studies have shown that α(1)-microglobulin protects against cell damage caused by oxi...

journal_title：Radiation research

authors： Olsson MG,Nilsson EJ,Rutardóttir S,Paczesny J,Pallon J,Akerström B

更新日期：2010-11-01 00:00:00

abstract：:In higher eukaryotes, DNA double-strand breaks (DSBs) induced by ionizing radiation activate checkpoints that delay progression through the cell cycle. Compared to delays in other phases of the cell cycle, delays induced in G(2) are longer and frequently correlate with resistance to killing by radiation. Therefore, mo...

journal_title：Radiation research

authors： Fan X,Cheong N,Iliakis G

更新日期：2010-10-01 00:00:00

abstract：:In light-ion radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered. In treatment optimization, it is advantageous to use a radiobiological model that analytically accounts for both dose and LET for the ion type of interest...

journal_title：Radiation research

authors： Wedenberg M,Lind BK,Toma-Daşu I,Rehbinder H,Brahme A

更新日期：2010-10-01 00:00:00

abstract：:Trypanothione is a unique diglutathionyl-spermidine conjugate found in abundance in trypanosomes but not in other eukaryotes. Because trypanothione is a naturally occurring polyamine thiol reminiscent of the synthetic drug amifostine, it may be a useful protector against radiation and oxidative stress. For these reaso...

journal_title：Radiation research

authors： Fitzgerald MP,Madsen JM,Coleman MC,Teoh ML,Westphal SG,Spitz DR,Radi R,Domann FE

更新日期：2010-09-01 00:00:00

abstract：:To determine the linear energy transfer (LET) dependence of the biological effects of densely ionizing radiation in relation to changes in the ionization density along the track, we measured the yields and spectrum of clustered DNA damages induced by charged particles of different atomic number but similar kinetic ene...

journal_title：Radiation research

authors： Keszenman DJ,Sutherland BM

更新日期：2010-08-01 00:00:00

abstract：:The detection of (41)Ca atoms in tooth enamel using accelerator mass spectrometry is suggested as a method capable of reconstructing thermal neutron exposures from atomic bomb survivors in Hiroshima and Nagasaki. In general, (41)Ca atoms are produced via thermal neutron capture by stable (40)Ca. Thus any (41)Ca atoms ...

journal_title：Radiation research

authors： Wallner A,Rühm W,Rugel G,Nakamura N,Arazi A,Faestermann T,Knie K,Maier HJ,Korschinek G

更新日期：2010-08-01 00:00:00

abstract：:The purpose of this study was to develop a rat orthotopic lung tumor model with a solitary intrapulmonary nodule to study the effects of high-dose radiation. A549-Luc non-small cell lung cancer (NSCLC) cells were implanted into nude rats in the intercostal space between ribs 5 and 6 of the right lung. Bioluminescence ...

journal_title：Radiation research

authors： Saha D,Watkins L,Yin Y,Thorpe P,Story MD,Song K,Raghavan P,Timmerman R,Chen B,Minna JD,Solberg TD

更新日期：2010-07-01 00:00:00

abstract：:The effects of ionizing radiation, with or without the anti-angiogenic agent anginex (Ax), on multiple myeloma growth were tested in a SCID-rab mouse model. Mice carrying human multiple myeloma cell-containing pre-implanted bone grafts were treated weekly with various regimens for 8 weeks. Rapid multiple myeloma growt...

journal_title：Radiation research

authors： Jia D,Koonce NA,Halakatti R,Li X,Yaccoby S,Swain FL,Suva LJ,Hennings L,Berridge MS,Apana SM,Mayo K,Corry PM,Griffin RJ

更新日期：2010-06-01 00:00:00

abstract：:This paper evaluates the global vitamin D effective UV (UV(vitd)) irradiances under cloudy conditions at a subtropical, southern hemisphere site. The UV(vitd) irradiances were analyzed on a horizontal plane and sampled at 5-min intervals over 18 months so that a wide range of parameters including cloud conditions, sol...

journal_title：Radiation research

authors： Turnbull DJ,Parisi AV,Schouten PW

更新日期：2010-05-01 00:00:00

abstract：:Tumor radiotherapy with large-field irradiation results in an increase of p53-dependent apoptosis of the radiosensitive hematopoietic stem cells. Proapoptotic PUMA is a transcriptional target of p53. Thus suppression of PUMA expression by gene therapy with the transcription repressor SNAI2 as transgene might be a pote...

journal_title：Radiation research

authors： Maier P,Herskind C,Barzan D,Zeller WJ,Wenz F

更新日期：2010-05-01 00:00:00

abstract：:This study was designed to determine changes in cell numbers, proliferation (using Ki-67) and EGFR expression in mouse bladder urothelium during the early and late radiation response. Groups of mice were irradiated with a single dose of 20 Gy and assayed 0-360 days later. Urothelial cells were counted. After immunohis...

journal_title：Radiation research

authors： Jaal J,Dörr W

更新日期：2010-04-01 00:00:00

abstract：:Abstract The present study was undertaken to investigate the ability of dietary supplements to reduce the formation and severity of cataracts in mice irradiated with high-energy protons or iron ions, which are important components of the radiation encountered by astronauts during space travel. The mice were exposed to...

journal_title：Radiation research

authors： Davis JG,Wan XS,Ware JH,Kennedy AR

更新日期：2010-03-01 00:00:00

abstract：:To characterize the differences in the radiosensitivity of individual populations of human hematopoietic stem/progenitor cells (HSPCs), we examined the relationship among cell surface antigens, clonogenic potential and radiation survival. The expressions of CD34, CD38, CD45RA, CD110 and Tie-2, early differentiation pa...

journal_title：Radiation research

authors： Takahashi K,Monzen S,Hayashi N,Kashiwakura I

更新日期：2010-02-01 00:00:00

abstract：:We previously described an enhanced sensitivity for cell killing and gamma-H2AX focus induction after both high-dose-rate and continuous low-dose-rate gamma irradiation in 14 primary fibroblast strains derived from hereditary-type retinoblastoma family members (both affected RB1(+/-) probands and unaffected RB1(+/+) p...

journal_title：Radiation research

authors： Wilson PF,Nagasawa H,Fitzek MM,Little JB,Bedford JS

更新日期：2010-01-01 00:00:00

abstract：:Ionizing radiation induces chronic metabolic oxidative stress and a mutator phenotype in hamster fibroblasts that is mediated by H(2)O(2), but the intracellular source of H(2)O(2) is not well defined. To determine the role of mitochondria in the radiation-induced mutator phenotype, end points of mitochondrial function...

journal_title：Radiation research

authors： Dayal D,Martin SM,Owens KM,Aykin-Burns N,Zhu Y,Boominathan A,Pain D,Limoli CL,Goswami PC,Domann FE,Spitz DR

更新日期：2009-12-01 00:00:00

abstract：:In a series of Russian and Ukrainian papers published from 1974-1986, it was reported that 30-day whole-body exposures to continuous-wave (CW) radiofrequency (RF) radiation at 2375 MHz and 5 W/m(2) disrupted the antigenic structure of rat brain tissue. The authors suggested that this action caused an autoimmune respon...

journal_title：Radiation research

authors： de Gannes FP,Taxile M,Duleu S,Hurtier A,Haro E,Geffard M,Ruffié G,Billaudel B,Lévêque P,Dufour P,Lagroye I,Veyret B

更新日期：2009-11-01 00:00:00

abstract：:To accurately quantify the number of single-strand breaks (SSBs) induced in plasmid DNA molecules after irradiation, a new type of assay methodology has been explored. The new method is based on the TUNEL (terminal deoxynucleotide transferase dUTP nick end-labeling) assay that was adopted for use under ELISA (enzyme-l...

journal_title：Radiation research

authors： Smiałek MA,Moore SA,Mason NJ,Shuker DE

更新日期：2009-11-01 00:00:00

abstract：:In boron neutron capture therapy, the absorbed dose from the (10)B(n,alpha)(7)Li reaction depends on the (10)B concentration and (10)B distribution in the irradiated volume. Thus compounds used in BNCT should have tumor-specific uptake and low accumulation in normal tissues. This study compares in a mouse model the (1...

journal_title：Radiation research

authors： Wittig A,Huiskamp R,Moss RL,Bet P,Kriegeskotte C,Scherag A,Hilken G,Sauerwein WA

更新日期：2009-10-01 00:00:00

abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...

journal_title：Radiation research

authors： Monzen S,Osuda K,Miyazaki Y,Hayashi N,Takahashi K,Kashiwakura I

更新日期：2009-09-01 00:00:00

abstract：:Abstract Pataky, K., Villanueva, G., Liani, A., Zgheib, O., Jenkins, N., Halazonetis, D. J., Halazonetis, T. D. and Brugger, J. Microcollimator for Micrometer-Wide Stripe Irradiation of Cells Using 20-30 keV X Rays. Radiat. Res. 172, 252-259 (2009). The exposure of subnuclear compartments of cells to ionizing radiatio...

journal_title：Radiation research

authors： Pataky K,Villanueva G,Liani A,Zgheib O,Jenkins N,Halazonetis DJ,Halazonetis TD,Brugger J

更新日期：2009-08-01 00:00:00

abstract：:Abstract Double-strand breaks (DSBs) can be generated in the DNA of mammalian cells when heat-labile sites induced by ionizing radiation within a clustered DNA damage site are thermally transformed to single-strand breaks (SSBs) and combine with other SSBs or heat-labile sites in the opposite DNA strand. When this the...

journal_title：Radiation research

authors： Singh SK,Wu W,Wu W,Wang M,Iliakis G

更新日期：2009-08-01 00:00:00

abstract：:Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes to radiation. The transcriptional response of quiescent primary fibroblasts and keratinocytes exposed to from 10 cGy to 5 Gy and ...

journal_title：Radiation research

authors： Warters RL,Packard AT,Kramer GF,Gaffney DK,Moos PJ

更新日期：2009-07-01 00:00:00

abstract：:The incidence of micronuclei was evaluated to assess the induction of an adaptive response to non-ionizing radiofrequency (RF) radiation in peripheral blood lymphocytes collected from five different human volunteers. After stimulation with phytohemagglutinin for 24 h, the cells were exposed to an adaptive dose of 900 ...

journal_title：Radiation research

authors： Sannino A,Sarti M,Reddy SB,Prihoda TJ,Vijayalaxmi,Scarfì MR

更新日期：2009-06-01 00:00:00

abstract：:The primary risk factors of multiple myeloma are age, race and sex, but several studies have found an association between radiological hazards and multiple myeloma. The purpose of this nested case-control study was to investigate whether workers with chronic low-level exposure to internally deposited uranium at the Oa...

journal_title：Radiation research

authors： Yiin JH,Anderson JL,Daniels RD,Seel EA,Fleming DA,Waters KM,Chen PH

更新日期：2009-06-01 00:00:00

abstract：:In an effort to identify proteomic changes that may be useful for radiation biodosimetry, human cells of hematological origin were treated with ionizing radiation or mock-irradiated and then harvested at different times after treatment. Protein lysates were generated from these cells and evaluated by Western blotting ...

journal_title：Radiation research

authors： Ivey RG,Subramanian O,Lorentzen TD,Paulovich AG

更新日期：2009-05-01 00:00:00